DRUG | HALF LIFE | ELIMINATION |
Warfarin | 35 hours | Hepatically metabolised, renal and faecal excretion |
Rivaroxaban | 5-9 hours (healthy) 11-13 hours (elderly) | 67% renal (half is inactive drug), 33% faecal |
Apixaban | 8-15 hours | 25% renal, 75% faecal |
Dabigatran | 12-17 hours (prolonged in renal impairment) | 80% renal. Diuresis must be maintained to promote adequate drug clearance. |
Clopidogrel | 6 hours | 50% renal, 50% faecal |
Ticagrelor | 9 hours | Metabolism by CYP-450 enzymes |